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[1]齐君,张桥,邹头君,等.碳酸酯共聚物的合成与性能[J].武汉工程大学学报,2011,(07):45-48.
　QI Jun,ZHANG Qiao,ZOU Toujun,et al.Synthesis and properties of poly(ethyl glycol)carbonate copolymers[J].Journal of Wuhan Institute of Technology,2011,(07):45-48.
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碳酸酯共聚物的合成与性能(/HTML)

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年07期
页码:
45-48
栏目:
材料科学与工程
出版日期:
2011-08-30

文章信息/Info

Title:
Synthesis and properties of poly(ethyl glycol)carbonate copolymers
文章编号:
16742869(2011)07004504
作者:
齐君; 张桥; 邹头君; 鄢国平*; 喻湘华; 李亮; 郭庆中; 杜飞鹏; 刘凡; 周丽
绿色化工过程省部共建教育部重点实验室，武汉工程大学材料与工程学院，湖北 武汉 430074
Author(s):
QI Jun;  ZHANG Qiao;  ZOU Toujun;  YAN Guoping;  YU Xianghua;  LI Liang;  GUO Qingzhong;  DU Feipeng;  LIU Fan;  ZHOU Li
Key Laboratory for Green Chemical Process of Ministry of Education, School of Materials Science
and Engineering, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
聚碳酸酯; 聚乙二醇; 开环聚合; 药物控制释放
Keywords:
Biomaterial;  poly(ethyl glycol);  ringopening polymerization;  drug controlled release
分类号:
O633
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2011.07.013
摘要:
用聚乙二醇(PEG，Mn=4000)引发9苯基2,4,8,10四氧螺［5,5］十一烷3酮(PTC)进行本体开环聚合反应，合成一系列侧链含有苄氧基团的脂肪族聚碳酸酯.然后用10％Pd/C催化剂对聚合物进行氢化还原反应，从而制得部分侧链含羟基的聚合物.并对所得聚合物进行GPC、1H NMR、FTIR、UV等结构表征，进一步研究了聚合物的体外释药性能.
Abstract:
?A series of carbonate copolymers were synthesized by the ringopening polymerization of 2phenyl5,5bis(oxymethyl) trimethylene carbonate (PTC) and poly(ethyl glycol) (PEG, Mn=4 000) using Sn(Oct)2 as a catalyst. These copolymers were further reduced by the Pd/C catalyst (10%) to produce the partly deprotected copolymers. These two type copolymers were characterized by 1H NMR, FTIR, UV, gel permeation chromatography (GPC), and automatic contact angle meter. In vitro release profiles of 5Fluorouracil of copolymers were also evaluated.

参考文献/References:

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［8］张敏,陈立班,秦刚,等．二氧化碳与环氧化物共聚催化剂［J］．化学通报，2002，65(6)：391395.
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［10］Shu Y Y, Xing G F, Li B C. Biodegradability of CO2 copolymers synthesized by using macromolecule bimetal catalysts ［J］. Polymers for Advanced Technologies.1996,7:605 608.
［11］Chen H, Yan G P, Li L, et al. Synthesis, characterization and properties of εcaprolactone and carbonate copolymers ［J］. Journal of Applied Polymer Science, 2009,114(5):30873096.
［12］Parzuchowski P G, Jaroch M. Synthesis of new glycerolbased hyperbranched polycarbonates ［J］. Macromolecules, 2008,41:38593865.
［13］Hu B, Yan G P, Wu Y, et al.?? Polycarbonate microspheres containing tumor necrosis factoralpha genes and magnetic powder as potential cancer therapeutics ［J］. Journal of Applied Polymer Science, 2008, 107(5):3343 3349.

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