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[1]叶正超,孙雪言,赵喜红*.无锡市某医院大肠杆菌耐药情况分析[J].武汉工程大学学报,2025,47(04):413-417.[doi:10.19843/j.cnki.CN42-1779/TQ.202310019]
　YE Zhengchao,SUN Xueyan,ZHAO Xihong*.Analysis of drug resistance in Escherichia coli in a Wuxi hospital[J].Journal of Wuhan Institute of Technology,2025,47(04):413-417.[doi:10.19843/j.cnki.CN42-1779/TQ.202310019]
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无锡市某医院大肠杆菌耐药情况分析
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
47
期数:
2025年04期
页码:
413-417
栏目:
现代大化工
出版日期:
2025-08-29

文章信息/Info

Title:
Analysis of drug resistance in Escherichia coli in a Wuxi hospital
文章编号:
1674 - 2869（2025）04 - 0413 - 05
作者:
武汉工程大学环境生态与生物工程学院，湖北 武汉 430205
Author(s):
School of Environmental Ecology and Biological Engineering,Wuhan Institute of Technology, Wuhan 430205, China
关键词:
Keywords:
分类号:
R446.5
DOI:
10.19843/j.cnki.CN42-1779/TQ.202310019
文献标志码:
A
摘要:
为了研究我国无锡地区大肠杆菌的耐药现状，采用最小抑菌浓度法进行药敏实验，对来源于无锡市某医院检验科的75株大肠杆菌进行氨苄西林、环丙沙星、诺氟沙星、四环素等8种抗生素耐药率检测，并研究其耐药进化和耐药稳定性。结果显示三重及以上抗生素耐药的菌株达73.3%，对氨苄西林、环丙沙星、诺氟沙星、四环素、复方新诺明、头孢噻吩的耐药率分别为92%、60%、53.3%、45.3%、49.3%、52%，对卡那霉素和氯霉素耐药率为12%和13.3%。大肠杆菌在抗生素长时间的胁迫下自身的耐药性普遍提高，且这种耐药性的变化可以被遗传。研究结果可为医生提供参考，以避免抗生素滥用，有利于推动抗生素的减少使用和综合管理。
Abstract:
To study Escherichia coli’s drug resistance in Wuxi area of China, the minimum inhibitory concentration (MIC) method was used for Escherichia coli’s drug sensitivity testing. Seventy-five isolates of Escherichia coli from the clinical laboratory of a hospital in Wuxi City were tested for resistance to 8 antibiotics such as ampicillin, ciprofloxacin, norfloxacin and tetracycline, and their resistance evolution and stability were studied. The results showed that the proportion of isolates resistant to three or more antibiotics reached 73.3%, with resistance rates to ampicillin, ciprofloxacin, norfloxacin, tetracycline, cotrimoxazole, cefalotin being 92%, 60%, 53.3%, 45.3%, 49.3% and 52%, respectively, and those to kanamycin and chloramphenicol were 12% and 13.3%, respectively. Under long-term stress of antibiotics, the drug resistance of Escherichia coli generally increased, and this change in resistance could be inheritable. These findings provide references for doctors to avoid antibiotic abuse, by promoting the reduction of antibiotics use and their comprehensive management.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：2023-10-24
基金项目：湖北省自然科学基金（2018CFB514）
作者简介：叶正超，硕士研究生。Email：1099162250@qq.com
*通信作者：赵喜红，博士，教授。Email：zxh@wit.edu.cn
引文格式：叶正超，孙雪言，赵喜红. 无锡市某医院大肠杆菌耐药情况分析［J］. 武汉工程大学学报，2025，47（2）：413-417.
更新日期/Last Update: 2025-08-29