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[1]王年航,喻志豪,于上媛,等.多功能复合水凝胶CMCS/OSA/PNIPAM的制备与性能研究[J].武汉工程大学学报,2026,48(01):63-69.[doi:10.19843/j.cnki.CN42-1779/TQ.202504001]
　WANG Nianhang,YU Zhihao,YU Shangyuan,et al.Preparation of multifunctional composite hydrogel CMCS/OSA/PNIPAM and its properties[J].Journal of Wuhan Institute of Technology,2026,48(01):63-69.[doi:10.19843/j.cnki.CN42-1779/TQ.202504001]
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多功能复合水凝胶CMCS/OSA/PNIPAM的制备与性能研究
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
48
期数:
2026年01期
页码:
63-69
栏目:
现代大化工
出版日期:
2026-02-28

文章信息/Info

Title:
Preparation of multifunctional composite hydrogel CMCS/OSA/PNIPAM and its properties
文章编号:
1674 - 2869（2026）01 - 0063 - 07
作者:
王年航1; 喻志豪1; 于上媛1; 田雪凡1; 2; 王 玮2; 吴江渝*1
1. 等离子体化学与新材料湖北省重点实验室（武汉工程大学），湖北 武汉 430205；
2. 材料成形与模具技术全国重点实验室（华中科技大学），湖北 武汉 430074
Author(s):
WANG Nianhang1; YU Zhihao1; YU Shangyuan1; TIAN Xuefan1; 2; WANG Wei2; WU Jiangyu*1
1. Hubei Key Laboratory of Plasma Chemistry and Advanced Materials（Wuhan Institute of Technology），Wuhan 430205，China；
2. State Key Laboratory of Material Processing and Die Mould Technology（Huazhong University of Science and Technology），Wuhan 430074，China
关键词:
N-异丙基丙烯酰胺; 氧化海藻酸钠; 羧甲基壳聚糖; 席夫碱; 温度响应
Keywords:
N-isopropylacrylamide; oxidized sodium alginate; carboxymethyl chitosan; Schiff base; temperature response
分类号:
TQ427.26
DOI:
10.19843/j.cnki.CN42-1779/TQ.202504001
文献标志码:
A
摘要:
本研究通过一锅法成功构建了一种基于羧甲基壳聚糖（CMCS）、氧化海藻酸钠（OSA）与聚N-异丙基丙烯酰胺（PNIPAM）的多功能复合水凝胶CMCS/OSA/PNIPAM（COP）。通过压缩试验研究了PNIPAM含量对水凝胶力学性能的影响，结果显示，随着PNIPAM含量的提高，水凝胶的压缩强度显著增强；当PNIPAM质量分数为6%时，压缩强度达到最大值20.8 kPa，相较未添加PNIPAM的水凝胶（0.5 kPa）提升约40倍。OSA含有活性醛基，与CMCS通过席夫碱反应形成动态共价键，赋予了COP水凝胶良好的自修复能力。流变学测试表明，当PNIPAM的质量分数为4%时，水凝胶展现出最佳的自修复能力，且在无外部刺激条件下于宏观尺度实现约2 h内的完全自愈。此外，COP水凝胶具备良好的温度响应性，其低临界溶解温度处于31~33 ℃之间，在50 ℃时发生明显体积收缩，失水率高达约41%，并出现显著的透明-浑浊的相转变现象，展现出智能温控材料的潜力。
Abstract:
In this study，a multifunctional composite hydrogel CMCS/OSA/PNIPAM （COP） based on carboxymethyl chitosan （CMCS），oxidized sodium alginate （OSA） and poly (N-isopropylacrylamide) （PNIPAM） was successfully synthesized via a one-pot method. Effect of PNIPAM content on the mechanical properties of COP was investigated through compression tests. Results demonstrated that the compressive strength of the hydrogel significantly increased with a higher PNIPAM content. At a PNIPAM mass fraction of 6%，the compressive strength reached a maximum value of 20.8 kPa，representing an approximately 40-fold enhancement compared to the hydrogel without PNIPAM (0.5 kPa). OSA contains active aldehyde groups，which react with CMCS to form dynamic covalent bonds via Schiff base reactions，endowing the COP hydrogel with excellent self-healing capability. Rheological tests revealed that the hydrogel exhibited optimal self-healing performance at a PNIPAM mass fraction of 4%，achieving complete macroscopic self-recovery within approximately 2 h without external stimuli. Furthermore，the COP hydrogel displayed remarkable temperature response，with a lower critical solution temperature between 31-33 ℃. At 50 ℃，it underwent significant volume contraction with a water loss rate of 41% and exhibited a distinct transparent-to-turbid phase transition，demonstrating potential as an intelligent temperature-controlled material.

参考文献/References:

[ 1 ] SANG F，LIU C S，YAN J Q，et al. Polysaccharide- and protein-based hydrogel dressings that enhance wound healing：a review [J]. International Journal of Biological Macromolecules，2024，280（Part 1）：135482.
[ 2 ] JIN J M， SUN C C， XU K Y，et al. Multifunctional self-healing peptide hydrogel for wound healing [J]. International Journal of Biological Macromolecules，2024，261（Part 1）：129734.
[ 3 ] LEI J F，LI X Y，WANG S，et al. Facile fabrication of biocompatible gelatin-based self-healing hydrogels [J]. ACS Applied Polymer Materials，2019，1（6）：1350-1358.
[ 4 ] XIE M M，ZENG Y B，WU H，et al. Multifunctional carboxymethyl chitosan/oxidized dextran/sodium alginate hydrogels as dressing for hemostasis and closure of infected wounds [J]. International Journal of Biological Macromolecules，2022，219：1337-1350.
[ 5 ] XIE T，VOGT B D. A virtual special issue on self-healing materials [J]. ACS Applied Materials & Interfaces，2020，12（44）：49277-49280.
[ 6 ] XIAN S J， WEBBER M J. Temperature-responsive supramolecular hydrogels [J]. Journal of Materials Chemistry B，2020，8（40）：9197-9211.
[ 7 ] WU J X， SHIN H G， LEE J H， et al. Preparation of external stimulus-free gelatin-catechol hydrogels with injectability and tunable temperature responsiveness [J]. ACS Applied Materials & Interfaces，2022，14（1）：236-244.
[ 8 ] LIN M Z， ZHENG Z J， YANG L， et al. A high-performance，sensitive，wearable multifunctional sensor based on rubber/CNT for human motion and skin temperature detection [J]. Advanced Materials，2022，34（1）：2107309.
[ 9 ] LEE Y M， LU Z W， WU Y C， et al. An injectable，chitosan-based hydrogel prepared by Schiff base reaction for anti-bacterial and sustained release applications [J]. International Journal of Biological Macromolecules，2024，269（Part 1）：131808.
[10] WANG L， WANG H N， DANG H M， et al. An adhesive，antibacterial hydrogel wound dressing fabricated by dopamine-grafted oxidized sodium alginate and methacrylated carboxymethyl chitosan incorporated with Cu(II) complex [J]. Biomaterials Advances，2025，170：214217.
[11] RASIB S Z M，AHMAD Z，KHAN A，et al. Synthesis and evaluation on pH- and temperature-responsive chitosan-p (MAA-co-NIPAM) hydrogels [J]. Interna-tional Journal of Biological Macromolecules，2018，108：367-375.
[12] WU P，FANG Y R，CHEN K Z，et al. Study of double network hydrogels based on sodium methacrylate alginate and carboxymethyl chitosan [J]. European Polymer Journal，2023，194：112137.
[13] ZU S，WANG Z H，ZHANG S，et al. A bioinspired 4D printed hydrogel capsule for smart controlled drug release [J]. Materials Today Chemistry，2022，24：100789.
[14] WANG Y Y，ADDISU K D，GEBRIE H T，et al. Multifunctional thermosensitive hydrogel based on alginate and p(NIPAM-co-HEMIN) composites for accelerated diabetic wound healing [J]. International Journal of Biological Macromolecules，2023，241：124540.
[15] LIU X Y， HU J J， HU Y C，et al. Multifunctional injectable oxidized sodium alginate/carboxymethyl chitosan hydrogel for rapid hemostasis [J]. Colloids and Surfaces B：Biointerfaces，2025，245：114346.
[16] LU X Y，LI Y L， GU X C，et al. Self-healable，self-adhesive conductive hydrogels based on integrated multiple interactions for wearable sensing [J]. Macromolecular Chemistry and Physics，2023，224（24）：2300228.
[17] TIAN X H， WEN Y T， ZHANG Z X， et al. Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing [J]. Biomaterials，2025，318：123134.
[18] 柴子铧，隋忠良，吴江渝，等. CMC/P(AA-AMPS)-Fe3+导电水凝胶的制备及在应变传感器中的应用[J]. 武汉工程大学学报，2024，46（6）：618-624.
[19] 候冰娜，倪凯，沈慧玲，等. 自修复氧化海藻酸钠-羧甲基壳聚糖水凝胶的制备及药物缓释性能[J]. 复合材料学报，2022，39（1）：250-257.
[20] 徐文静，梁建荣，曲萌菲，等. 乙二醇壳聚糖自愈合水凝胶的制备及性能[J]. 材料工程，2023，51（11）：144-150.

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备注/Memo

备注/Memo:
收稿日期：2025-04-02
基金项目：国家自然科学基金（52177216）
作者简介：王年航，硕士研究生。Email：2826017147@qq.com
*通信作者：吴江渝，博士，教授。Email：wujy@wit.edu.cn
更新日期/Last Update: 2026-03-09