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[1]彭晨俊男,罗晓刚*. pH响应性羧甲基化纤维素微球原位生长UiO-66及用于双氯芬酸钠的控释 [J].武汉工程大学学报,2026,48(02):149-158.[doi:10.19843/j.cnki.CN42-1779/TQ.202601006]
　PENG Chenjunnan,LUO Xiaogang*. In situ growth of UiO-66 on pH-responsive carboxymethylated cellulose microspheres for controlled release of diclofenac sodium [J].Journal of Wuhan Institute of Technology,2026,48(02):149-158.[doi:10.19843/j.cnki.CN42-1779/TQ.202601006]
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pH响应性羧甲基化纤维素微球原位生长UiO-66及用于双氯芬酸钠的控释
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
48
期数:
2026年02期
页码:
149-158
栏目:
现代大化工
出版日期:
2026-04-30

文章信息/Info

Title:
In situ growth of UiO-66 on pH-responsive carboxymethylated cellulose microspheres for controlled release of diclofenac sodium
文章编号:
1674 - 2869（2026）02 - 0149 - 10
作者:
彭晨俊男; 罗晓刚*
武汉工程大学化工与制药学院，绿色化工过程教育部重点实验室（武汉工程大学），湖北 武汉 430205
Author(s):
PENG Chenjunnan; LUO Xiaogang*
School of Chemical Engineering and Pharmacy，Wuhan Institute of Technology；Key Laboratory of Green Chemical Process of Ministry of Education（Wuhan Institute of Technology），Wuhan 430205，China
关键词:
羧甲基化纤维素微球; UiO-66; 原位合成; 双氯芬酸钠; 控释载体
Keywords:
carboxymethyl-modified cellulose microsphere; UiO-66; in situ synthesis; diclofenac sodium; controlled release carrier
分类号:
X703
DOI:
10.19843/j.cnki.CN42-1779/TQ.202601006
文献标志码:
A
摘要:
首先通过氯乙酸钠与纤维素微球（CM）进行醚化反应制备羧甲基化纤维素微球（CMC-M），然后以CMC-M为生物聚合物骨架原位生长锆基金属有机骨架（UiO-66），成功制备了锆基金属有机框架/羧甲基化纤维素复合微球（UiO-66@CMC-M），并以双氯芬酸钠（DCF）为模型药物研究了其药物负载和控释能力。通过扫描电子显微镜、能量色散X射线光谱、傅里叶变换红外光谱、X射线衍射和热重分析等表征证实了UiO-66晶体围绕CMC-M骨架的成功复合，且CMC-M上的羧基可能与UiO-66的Zr4+节点发生配位键合。药物负载实验表明DCF的负载主要受物理和化学吸附共同控制，且为单层吸附。体外释放研究证实了DCF@UiO-66@CMC-M的pH响应性控释能力。在模拟胃酸条件（pH=1.2）下，DCF在70 h累计释放约24%，而在模拟肠道条件（pH=7.4）下，70 h累计释放约80%。释放动力学拟合结果显示，药物释放遵循Korsmeyer-Peppas模型，且释放机制符合Fickian扩散。细胞毒性实验进一步证实了UiO-66@CMC-M具有良好的生物相容性和极低的细胞毒性。本研究为设计一种DCF的新型控释载体提供了理论依据。
Abstract:
Carboxymethylated cellulose microspheres （CMC-M） were first synthesized via etherification of cellulose microspheres （CM） with sodium chloroacetate. Subsequently，zirconium-based metal-organic framework UiO-66 was grown in situ onto the CMC-M biopolymer backbone to successfully fabricate UiO-66@CMC-M composite microspheres. The drug loading and controlled release performance of the composite were then evaluated using diclofenac sodium （DCF） as a model drug. Characterization results from scanning electron microscopy，energy-dispersive X-ray spectroscopy，Fourier-transform infrared spectroscopy，X-ray diffraction，and thermogravimetric analysis confirmed the successful integration of UiO-66 crystals on the CMC-M framework，suggesting potential coordination bonding between the carboxyl groups on CMC-M and the Zr4+ nodes of UiO-66. Drug loading experiments indicated that DCF loading was governed by a combination of physical and chemical interactions，leading to monolayer adsorption. In vitro release studies demonstrated pH-responsive controlled release behavior of DCF@UiO-66@CMC-M. Under simulated gastric fluid （pH＝1.2），the cumulative release of DCF was approximately 24% over 70 h，whereas it reached approximately 80% under simulated intestinal fluid （pH＝7.4）. Kinetic fitting revealed that the drug release profile followed the Korsmeyer-Peppas model，with the mechanism consistent with Fickian diffusion. Cytotoxicity assays further confirmed that UiO-66@CMC-M possesses excellent biocompatibility and negligible cytotoxicity. This study provides a theoretical foundation for the design of novel controlled-release carriers for DCF.

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备注/Memo

备注/Memo:
收稿日期：2026-01-19
基金项目：湖北省重点研发计划项目（2022BAB109，2024BEB002）
作者简介：彭晨俊男，硕士研究生。Email：2230093351@qq.com
*通信作者：罗晓刚，博士，教授。Email：xgluo0310@hotmail.com
更新日期/Last Update: 2026-05-07