|本期目录/Table of Contents|

[1]杨紫月,陈 礼,吴江渝,等.丝素蛋白在生物医用中的改性方法及研究进展[J].武汉工程大学学报,2026,48(03):287-295.[doi:10.19843/j.cnki.CN42-1779/TQ.202601005]
　YANG Ziyue,CHEN Li,WU Jiangyu,et al.Modification methods and research progress of silk fibroin for biomedical applications[J].Journal of Wuhan Institute of Technology,2026,48(03):287-295.[doi:10.19843/j.cnki.CN42-1779/TQ.202601005]
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丝素蛋白在生物医用中的改性方法及研究进展
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
48
期数:
2026年03期
页码:
287-295
栏目:
现代大化工
出版日期:
2026-06-30

文章信息/Info

Title:
Modification methods and research progress of silk fibroin for biomedical applications
文章编号:
1674 - 2869（2026）03 - 0287 - 09
作者:
杨紫月; 陈 礼; 吴江渝; 曾小平; 王 帅; 喻志豪; 刘倩倩; 王大威*
武汉工程大学材料科学与工程学院，湖北 武汉 430205
Author(s):

School of Materials Science and Engineering，Wuhan Institute of Technology，Wuhan 430205， China
关键词:
丝素蛋白; 改性丝素; 生物医用; 物理交联; 化学交联; 研究进展
Keywords:
silk fibroin; modified silk fibroin; biomedical application; physical crosslinking; chemical crosslinking; research progress
分类号:
TQ317.9
DOI:
10.19843/j.cnki.CN42-1779/TQ.202601005
文献标志码:
A
摘要:
丝素蛋白（SF）作为天然生物聚合物，具备优异生物相容性、可控降解性与加工灵活性，在生物医学领域应用广泛，但天然状态下仍存在脱胶不彻底易诱发机体炎症反应，加工成型过程中力学性能易劣化，且体内降解速率难以精准调控等局限。综述了SF的物理改性（共混、结构调控）、化学改性（交联、接枝）及生物改性（基因编辑、添食）三类核心方法，详细阐述了各改性技术的使用材料、制备工艺与性能优势：填充改性可赋予材料磁响应性与抗菌性，交联改性能显著提升力学性能，生物改性可从源头优化SF特性。同时，系统介绍了改性SF纤维在组织工程支架、医用功能敷料、药物递送与控释系统等领域的应用进展，包括多层人工血管、骨组织重建支架、抗菌伤口敷料及智能药物载体等具体场景。最后指出，改性SF材料已突破天然SF的性能瓶颈，但其改性条件温和化与改性程度精准调控仍是亟待解决的问题，未来需围绕该方向深化研究，进一步拓展其在生物医学领域的应用潜力，为相关学科发展提供重要参考。
Abstract:
As a natural biopolymer，silk fibroin （SF） possesses excellent biocompatibility，controllable degradability，and versatile processability，making it extensively applicable in the biomedical field. However，native SF has inherent limitations，including inflammation caused by incomplete degumming， deterioration of mechanical properties during fabrication，and poor controllability of in vivo biodegradation rate. In this review, we summarized three core modification strategies for SF：physical modification （blending，and structural regulation），chemical modification （crosslinking，grafting），and biological modification （gene editing，dietary supplementation）. The materials，preparation methods，and performance advantages of each modification technique were elaborated in detail. Specifically，filler incorporation endows the materials with magnetic responsiveness and antibacterial activity，crosslinking modification significantly enhances mechanical performance，and biological modification enables the optimization of SF properties at the source. Furthermore，the application progress of modified SF fibers in key biomedical areas—such as tissue engineering scaffolds，medical functional dressings，and drug delivery/controlled-release systems—was systematically reviewed，including specific examples such as multilayered artificial blood vessels，bone tissue reconstruction scaffolds，antibacterial wound dressings，and smart drug carriers. Finally，it was noted that modified SF materials have overcome the performance bottlenecks of natural SF. However，achieving mild modification conditions and precise control over the degree of modification remains challenging. Future research should focus on these directions to further expand the biomedical application potential of SF，thereby providing valuable insights for the advancement of related disciplines.

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备注/Memo

备注/Memo:
收稿日期：2026-01-11
基金项目：国家自然科学基金（82302818）
作者简介：杨紫月，硕士研究生。Email：2689900637@qq.com
*通信作者：王大威，博士，副教授。Email：wangdawei@wit.edu.cn
更新日期/Last Update: 2026-06-26