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[1]喻志豪,杨紫月,孔凡天,等.基于丝素的抗菌纤维膜的制备及性能研究[J].武汉工程大学学报,2025,47(04):385-392.[doi:10.19843/j.cnki.CN42-1779/TQ.202504006]
　YU Zhihao,YANG Ziyue,KONG Fantian,et al.Preparation and properties of antibacterial fiber membrane based on silk fibroin[J].Journal of Wuhan Institute of Technology,2025,47(04):385-392.[doi:10.19843/j.cnki.CN42-1779/TQ.202504006]
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基于丝素的抗菌纤维膜的制备及性能研究
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
47
期数:
2025年04期
页码:
385-392
栏目:
现代大化工
出版日期:
2025-08-29

文章信息/Info

Title:
Preparation and properties of antibacterial fiber membrane based on silk fibroin
文章编号:
1674 - 2869（2025）04 - 0385 - 08
作者:
1. 武汉工程大学材料科学与工程学院，湖北 武汉 430205；2. 汉江国家实验室，湖北 武汉 430060；
3. 中部战区总医院烧伤整形科，湖北 武汉 430061
Author(s):
1. School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China;
2. Hanjiang National Laboratory, Wuhan 430060, China; 3. Burn and Plastic Surgery Department,
Central Theater Command General Hospital, Wuhan 430061, China
关键词:
Keywords:
分类号:
TQ317.9
DOI:
10.19843/j.cnki.CN42-1779/TQ.202504006
文献标志码:
A
摘要:
通过引入甲基丙烯酰化明胶（GelMA）和甲基丙烯酰化聚赖氨酸（PLMA）改善丝素（SF）纤维膜的亲水性和抗菌性。将GelMA引入SF，制备了GelMA/SF（GS）纤维膜，随后将PLMA作为抗菌组分引入GS纤维膜，制备了PLMA/GS（P/GS）纤维膜。核磁共振氢谱表征证实了GelMA和PLMA的成功合成；傅里叶变换红外光谱证实了所有的纤维膜中的SF在交联后发生了构象转变；扫描电子显微镜观察到所有纤维的形态均呈现扁平状；研究了GelMA和PLMA的引入对纤维膜拉伸性能、亲水性能和抗菌性能的影响。结果表明，PLMA质量分数5%的GS（5%P/GS）纤维膜综合性能最佳，其拉伸性能与SF纤维膜和GS纤维膜相差不大；与SF纤维膜相比，GS纤维膜的水接触角由85.5°降低至54.8°；与GS纤维膜相比，5%P/GS纤维膜的水接触角更低，为52.3°；5%P/GS纤维膜具备优异的抗菌性，并且PLMA不会从纤维膜中溶出损失。因此，5%P/GS纤维膜具有潜在的生物医用价值，尤其在伤口敷料方面。
Abstract:
To enhance the hydrophilicity and antibacterial properties of silk fibroin (SF) fiber membranes，gelatin methacryloyl (GelMA) and polylysine methacryloyl (PLMA) were introduced. GelMA/SF (GS) fiber membranes were prepared by introducing GelMA into SF, and then PLMA was introduced into GS fiber membrane as antibacterial component to prepare PLMA/GS (P/GS) fiber membrane. Successful synthesis of GelMA and PLMA was confirmed by 1H nuclear magnetic resonance (1H NMR) spectroscopy. Fourier-transform infrared (FTIR) spectroscopy verified conformational transition of SF in all fiber membranes post-crosslinking. Scanning electron microscopy (SEM) revealed flattened fiber morphology across all samples. The effects of GelMA and PLMA incorporation on tensile properties, hydrophilicity and antibacterial properties of the fiber membranes were systematically investigated. Results demonstrated that the GS membrane with a PLMA mass fraction of 5% (5%P/GS) exhibited optimal overall performance. Its tensile properties showed no significant difference from pure SF or GS membranes. Compared with the SF fiber membrane, the water contact angle of the GS fiber membrane decreases from 85.5° to 54.8°. The 5%P/GS membrane displayed further improved hydrophilicity with a contact angle of 52.3°. Critically, the 5%P/GS membrane demonstrated excellent antibacterial activity without PLMA leaching. These findings indicated that 5%P/GS fiber membranes hold significant potential for biomedical applications, particularly as wound dressings.


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备注/Memo

备注/Memo:
收稿日期：2025-04-09
基金项目：国家自然科学基金（82302818）
作者简介：喻志豪，硕士研究生。Email：zhihaoyu2000@126.com
*通信作者：王大威，博士，副教授。Email：wangdawei@wit.edu.cn：
引文格式：喻志豪，杨紫月，孔凡天，等. 基于丝素的抗菌纤维膜的制备及性能研究［J］. 武汉工程大学学报，2025，47（4）：385-392.
更新日期/Last Update: 2025-08-29