|本期目录/Table of Contents|

[1]吴江渝,董兴梅,肖夏.聚酰胺胺树形分子的叶酸修饰及其表征[J].武汉工程大学学报,2013,(01):36-40.[doi:16742869(2013)01003605]
　WU Jiang yu,DONG Xing mei,XIAO Xia.Synthesis and characterization of folic acidmodified?polyamidoamine dendrimers[J].Journal of Wuhan Institute of Technology,2013,(01):36-40.[doi:16742869(2013)01003605]
点击复制

聚酰胺胺树形分子的叶酸修饰及其表征(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2013年01期
页码:
36-40
栏目:
资源与土木工程
出版日期:
2013-01-31

文章信息/Info

Title:
Synthesis and characterization of folic acidmodified?polyamidoamine dendrimers
文章编号:
103969/jissn16742869201301008
作者:
吴江渝;  董兴梅; 肖夏
武汉工程大学材料科学与工程学院，湖北 武汉 430074
Author(s):
WU Jiangyu ; DONG Xingmei;  XIAO Xia
School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
树形分子; 叶酸; 肿瘤靶向性; 红外光谱; 紫外-可见光谱; 接枝率
Keywords:
dendrimer;  folic acid;  tumor targeting;  FTIR spectra;  UVvis spectra;  grafting ratio
分类号:
0633.4
DOI:
16742869(2013)01003605
文献标志码:
A
摘要:
聚酰胺胺（Polyamidoamine, PAMAM）树形分子是一种广泛用于药物载体和基因载体研究的合成大分子.由于肿瘤细胞表面具有大量表达的叶酸受体，在树形分子末端接枝上叶酸分子可以增强该化合物的肿瘤靶向性.通过发散法合成了0到4代乙二胺为核的聚酰胺胺树形分子并进行叶酸接枝修饰.利用红外光谱及紫外-可见光谱分析，对所得到的树形分子-叶酸化合物进行了结构表征.结果表明：以吡啶作为催化剂叶酸接枝效果较好，通过与叶酸紫外吸收标准曲线对比计算，零代树形分子-叶酸共轭化合物的平均接枝率约为31%，一代至四代树形分子-叶酸共轭化合物的平均接枝率分别为28%、36%、15%和10%.
Abstract:
Polyamidoamine (PAMAM) dendrimers are synthetic molecules which are now widely used as vectors in drugs delivery and gene transfer research. Since folic acid (FA) receptor is overexpressed on the surface of tumor cells, the tumortargeting effect of dendrimers can be improved though grafting folic acid at the terminal of the dendrimer molecules. Ethylenediaminecore PAMAM dendrimers with generation 0 through 4 were synthesized using divergent strategy, and folic acid molecules were grafted onto the dendrimer surface. The obtained dendrimerFA compounds were characterized by FTIR and UVvis spectra. The results show that pyridine is a good catalyst for the folic acid grafting. The grafting ratio of G0PAMAMFA is about 31% and the ratios for the grafted G0G4 PAMAM dendrimers are 28%, 36%, 15% and 10%, respectively.

参考文献/References:

［1］Majoros I J, Thomas T P, Mehta C B, et al. Poly (amidoamine) DendrimerBased Multifunctional Engineered Nanodevice for Cancer Therapy\[J\]. Journal of Medicinal Chemistry, 2005, 48:58925899.

［2］Majoros I J, Myc A ,Thomas T, et al. PAMAM DendrimerBased Multifunctional Conjugate for Cancer Therapy: Synthesis, Characterization, and Functionality\[J\]. Biomacromolecules, 2006, 7: 572579.
［3］Wiwattanapatapee R, Carren oGo’mez B, Malik N, et al. Anionic PAMAM Dendrimers Rapidly Cross Adult Rat Intestine In Vitro: A Potential Oral Delivery System\[J\]. Pharmaceutical Research, 2000, 17(8):991998.
［4］Zhu S J, Hong M H, Zhang L H, et al. PEGylated PAMAM DendrimerDoxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation\[J\]. Pharmaceutical Research, 2010, 27(1):161174.
［5］徐海娥, 闫翠娥. 叶酸和聚乙二醇接枝作基因载体用壳聚糖的合成与表征\[J\]. 化学研究与应用， 2007, 19(1):6063.［6］Shi X Y, Wang S H, Shen M W, et al. Multifunctional DendrimerModified Multiwalled Carbon Nanotubes: Synthesis, Characterization, and In Vitro Cancer Cell Targeting and Imaging\[J\]. Biomacromolecules, 2009, 10: 17441750.［7］Zhang Y Q, Sun Y H, Xu X P, et al. Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)Folic Acid Conjugates\[J\]. Journal of Medicinal Chemistry, 2010, 53: 32623272.
［8］姜铁坤，吴江渝，肖夏，等.微波条件下树形分子核单元的合成及优化\[J\].武汉工程大学学报，2010,32(11)：7073.

相似文献/References:

[1]李妍,吴江渝*.单边发散型树形分子的合成研究与表征[J].武汉工程大学学报,2010,(03):72.
　LI Yan,WU Jiang yu.nilateral divergent dendrimer synthesis studies and characterization[J].Journal of Wuhan Institute of Technology,2010,(01):72.
[2]姜铁坤,吴江渝,肖夏,等.微波条件下树形分子核单元的合成及优化[J].武汉工程大学学报,2010,(11):70.[doi:10.3969/j.issn.16742869.2010.11.018]
　JIANG Tie kun,WU Jiang yu,XIAO Xia,et al.Microwave assisted synthesis of core unit of PAMAM dendrimer[J].Journal of Wuhan Institute of Technology,2010,(01):70.[doi:10.3969/j.issn.16742869.2010.11.018]
[3]肖夏,吴江渝*.以二乙醇胺为核聚酰胺胺树形分子的合成及表征[J].武汉工程大学学报,2011,(11):43.
　XIAO Xia,WU Jiang yu.Synthesis and characterization of polyamidoaminedendrimers using diethanolamine as core[J].Journal of Wuhan Institute of Technology,2011,(01):43.
[4]吴江渝,黄维哲,周婷,等.三（2氨基乙基）胺核聚酰胺胺树形分子的合成[J].武汉工程大学学报,2014,(04):45.[doi:103969/jissn16742869201404010]
　WU Jiang yu,HUANG Wei zhe,ZHOU Ting,et al.Synthesis and characterization of polyamidoamine dendrimer using tris(2aminoethyl)amine as core[J].Journal of Wuhan Institute of Technology,2014,(01):45.[doi:103969/jissn16742869201404010]

备注/Memo

备注/Memo:
收稿日期：20121022基金项目：国家自然科学基金（No. 51003081）；武汉市青年科技晨光计划项目( 200950431195)作者简介：吴江渝(1977),男,湖北武汉人,教授,硕士研究生导师.研究方向：树形分子合成及应用，丙烯酸系聚合物合成及应用，纳米材料制备.
更新日期/Last Update: 2013-04-09