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[1]余思忆,谢子龙,吴剑坤,等.连续流微通道反应器中分子氧催化氧化环己烷制备KA油的研究[J].武汉工程大学学报,2026,48(01):1-08.[doi:10.19843/j.cnki.CN42-1779/TQ.202502012]
　YU Siyi,XIE Zilong,WU Jiankun,et al.Catalytic oxidation of cyclohexane to prepare KA oil in a continuous-flow microreactor using molecular oxygen[J].Journal of Wuhan Institute of Technology,2026,48(01):1-08.[doi:10.19843/j.cnki.CN42-1779/TQ.202502012]
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连续流微通道反应器中分子氧催化氧化环己烷制备KA油的研究
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
48
期数:
2026年01期
页码:
1-08
栏目:
现代大化工
出版日期:
2026-02-28

文章信息/Info

Title:
Catalytic oxidation of cyclohexane to prepare KA oil in a continuous-flow microreactor using molecular oxygen
文章编号:
1674 - 2869（2026）01 - 0001 - 08
作者:
余思忆1; 谢子龙1; 吴剑坤2; 刘佳伍1; 王建芝1; 刘艳萍1; 刘 捷1; 林 笑1; 喻发全*1
1.武汉工程大学化工与制药学院，湖北 武汉 430205；
2.宜昌人福药业有限责任公司，湖北 宜昌 443005
Author(s):
1. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology，Wuhan 430205，China；
2. Yichang Humanwell Pharmaceutical Co., Ltd，Yichang 443005，China
关键词:
环己烷; 氧化; 连续流微反应器; KA油
Keywords:
cyclohexane;  oxidation;  continuous-flow microreactor;  KA oil
分类号:
TQ244
DOI:
10.19843/j.cnki.CN42-1779/TQ.202502012
文献标志码:
A
摘要:
设计了一种连续流动微通道反应器，用于通过环己烷的催化氧化制备KA油（环己酮和环己醇的混合物），采用水热法合成的铈锰钴复合氧化物（CeMnCoOx）作为催化剂，氧气作为氧化剂。通过扫描电子显微镜、透射电子显微镜、X射线衍射分析和X射线光电子能谱等表征技术，证实了催化剂具有优异的均匀性、比表面积以及稳定的晶体结构和化学组成。将催化剂负载在玻璃珠上并填充到反应管中形成微通道，增加了界面接触面积，提升了反应效率。研究了填充直径、反应温度、压力、氧气流量和停留时间对反应的影响。结果表明，在填充直径为1.0~1.5 mm、液体流速为0.1 mL·min-1、氧气流量为40 mL·min-1、反应温度为160 ℃、压力为1.0 MPa的条件下，停留时间约为32 min，环己烷转化率达到11.88%，KA油收率达到5.43%。与传统的间歇式工艺相比，该连续流微通道反应器显著缩短了反应时间，提高了生产效率，为KA油的高效生产提供了新途径。
Abstract:
In this study, we designed a continuous-flow microchannel reactor for the prepararion of KA oil (a mixture of cyclohexanone and cyclohexanol) through catalytic oxidation of cyclohexane. A cerium-manganese-cobalt composite oxide (CeMnCoOx) catalyst, synthesized by a hydrothermal method, was employed with oxygen as the oxidant. Characterization techniques including SEM, TEM, XRD, and XPS confirmed the catalyst’s excellent uniformity, high specific surface area, and stable crystal structure and chemical composition. The catalyst was loaded onto glass beads and packed into reaction tubes to form microchannels, which significantly enhanced the interfacial contact area and improved reaction efficiency. The effects of key parameters were systematically investigated, including packing diameter, reaction temperature, pressure, oxygen flow rate, and residence time. Under the optimized conditions of a packing diameter of 1.0-1.5?mm, liquid flow rate of 0.1?mL·min-1, oxygen flow rate of 40?mL·min-1, reaction temperature of 160?℃, and pressure of 1.0?MPa, the residence time was approximately 32?min, resulting in a cyclohexane conversion of 11.88% and a KA oil yield of 5.43%. Compared with conventional batch processes, this continuous-flow microreactor?significantly reduces reaction time, improves production efficiency, and offers a promising route for efficient synthesis of KA oil.

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备注/Memo

备注/Memo:
收稿日期：2025-03-04
基金项目：国家自然科学基金(22078251)；湖北省科技厅重点项目(2023DJC167)
作者简介：余思忆，硕士研究生。Email：215558467@qq.com
*通讯作者：喻发全，博士，教授。Email：fyu@wit.edu.cn
更新日期/Last Update: 2026-03-09