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[1]王晓炜,叶 琦.硫酸锌糖浆稳定性的研究[J].武汉工程大学学报,2017,39(04):331-336.[doi:10. 3969/j. issn. 1674?2869. 2017. 04. 005]
 WANG Xiaowei,YE Qi.Investigation of Stability of Zinc Sulfate Syrup[J].Journal of Wuhan Institute of Technology,2017,39(04):331-336.[doi:10. 3969/j. issn. 1674?2869. 2017. 04. 005]
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硫酸锌糖浆稳定性的研究(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
39
期数:
2017年04期
页码:
331-336
栏目:
化学与化学工程
出版日期:
2017-10-14

文章信息/Info

Title:
Investigation of Stability of Zinc Sulfate Syrup
文章编号:
20170405
作者:
王晓炜叶 琦
马应龙药业集团股份有限公司,湖北 武汉 430064
Author(s):
WANG Xiaowei YE Qi
Mayinglong Pharmaceutical Group Co. LTD, Wuhan 430064, China
关键词:
硫酸锌糖浆枸橼酸-枸橼酸钠缓冲液pH稳定剂
Keywords:
zinc sulfate syrup citric acid sodium citrate buffer solution pH stabilizer
分类号:
R977.9
DOI:
10. 3969/j. issn. 1674?2869. 2017. 04. 005
文献标志码:
A
摘要:
为解决硫酸锌糖浆贮存期间稳定性下降的问题,以一水枸橼酸—二水枸橼酸钠缓冲液作为硫酸锌糖浆的稳定剂,研究了两者不同的质量浓度比例、质量浓度总量对硫酸锌糖浆pH值稳定的效果,确定加有一水枸橼酸(质量浓度为0.35 g/L)和二水枸缘酸钠(质量浓度为3.15 g/L)缓冲溶液的硫酸锌糖浆,720 d的效期内pH值下降了6.8%,未加pH稳定剂的硫酸锌糖浆pH值720 d的效期内下降了44%,差异显著;结果表明1L硫酸锌糖浆溶液中,一水枸橼酸质量浓度∶二水枸缘酸钠质量浓度=1∶3,两者质量浓度总量为3.5 g/L的缓冲溶液,可明显提高硫酸锌糖浆pH值的效果较好,产品品质得到很的提升
Abstract:
To solve the decline of zinc sulfate syrup’s stability, we used the citric acid monohydrate and sodium citrate dehydrate buffer solution as the stabilizer of zinc sulfate syrup. We also studied the effect of total mass concentration and different ratios of the two compounds on the pH of zinc sulfate syrup. We find that when citric acid monohydrate and sodium citrate dehydrate with mass concentration of 0.35 g/L and 3.15 g/L respectively are added to zinc sulfate syrup, the pH has only decreased by 6.8% in the following 720 d validity term while the pH of zinc sulfate syrup decreases by 44% without adding pH stabilizer during the same period. The difference is significant. So we confirm that adding citric acid monohydrate and sodium citrate dehydrate at ratio of 1∶3 and total mass concentration of 3.5 g/L in 1 L zinc sulfate syrup can obtain better stability and improves the products quality.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2017-02-10 作者简介:王晓炜,高级工程师. E-mail:wxw1019@163.com
更新日期/Last Update: 2017-08-04