|本期目录/Table of Contents|

[1]王映桂,张思洁,刘　璨,等.可降解自愈合壳聚糖/瓜尔胶水凝胶的制备与性能[J].武汉工程大学学报,2020,42(03):302-306.[doi:10.19843/j.cnki.CN42-1779/TQ.202002001]
　WANG Yinggui,ZHANG Sijie,LIU Can,et al.Preparation and Properties of Degradable and Self-Healing Chitosan/Guar Gum Hydrogels[J].Journal of Wuhan Institute of Technology,2020,42(03):302-306.[doi:10.19843/j.cnki.CN42-1779/TQ.202002001]
点击复制

可降解自愈合壳聚糖/瓜尔胶水凝胶的制备与性能(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
42
期数:
2020年03期
页码:
302-306
栏目:
材料科学与工程
出版日期:
2023-03-14

文章信息/Info

Title:
Preparation and Properties of Degradable and Self-Healing Chitosan/Guar Gum Hydrogels
文章编号:
1674 - 2869（2020）03 - 0302 - 05
作者:
王映桂; 张思洁; 刘　璨; 曾小平; 王大威; 吴江渝*
武汉工程大学材料科学与工程学院，湖北 武汉 430205
Author(s):
WANG Yinggui; ZHANG Sijie; LIU Can; ZENG Xiaoping; WANG Dawei; WU Jiangyu*
School of Materials Science and Engineering，Wuhan Institute of Technology，Wuhan 430205， China
关键词:
瓜尔胶; 壳聚糖; 可降解; 自愈合; 水凝胶
Keywords:
guar gum;  chitosan;  degradable;  self-healing;  hydrogel
分类号:
O636.1
DOI:
10.19843/j.cnki.CN42-1779/TQ.202002001
文献标志码:
A
摘要:
可降解自愈合水凝胶在生物医用领域有广泛的应用前景，然而其设计仍面临很大的挑战。用高碘酸钠氧化瓜尔胶（GG）得到醛基化瓜尔胶（AGG）。将AGG与壳聚糖（CS）混合，AGG链上的醛基与CS链上的氨基进行席夫碱（Schiff base）反应形成动态亚胺键，从而得到壳聚糖/醛基化瓜尔胶（CS/AGG）水凝胶。该水凝胶拥有较好的自愈合性和可降解性。利用核磁共振氢谱（1H-NMR）对AGG进行了结构表征，结果表明GG成功被氧化成AGG。利用动态流变性能测试对水凝胶进行模量表征，频率扫描结果表明当CS和AGG的体积比在1∶5时水凝胶储能模量最高为400 Pa；动态交替时间扫描结果表明该水凝胶能在5 min内实现快速自愈合。降解性能测试表明CS/AGG水凝胶在pH=6.8和pH=7.4的环境下7 d内降解率可达65%。所制备的CS/AGG水凝胶的自愈合性和可降解性为其在可降解医用伤口敷料和药物释放等方面的应用提供能了可能性。
Abstract:
Degradable and self-healing hydrogels are widely used in biomedical field，while the design of hydrogel structure is still a challenge. Herein we developed chitosan/aldehyde guar gum （CS/AGG） hydrogels by mixing CS and AGG which resulted from the oxidization of guar gum （GG） by sodium periodate. Schiff base reaction occurred between aldehyde groups of AGG and amino groups of CS to form dynamic imine linkages. The CS/AGG hydrogels present good self-healing and degradable properties. 1H-nuclear magnetic resonance spectroscopy （1H-NMR） was utilized to characterize the chemical structure of AGG，and the result indicates that the GG is successfully oxidized to AGG. The dynamic rheological tests were used to measure the modulus of hydrogels. The result of frequency scan shows that the highest modulus of hydrogels is around 400 Pa when the volume ratio of CS and AGG is 1∶5. In addition，the results of dynamic alternate time scan show that the self-healing process of CS/AGG hydrogels can finish in 5 min. Degradation tests demonstrate that the hydrogel reaches a high degradation of 65% at pH 6.8 and 7.4 in 7 days. These results indicate that CS/AGG hydrogels can be applied in degradable wound dressings and drug delivery due to their self-healing and degradable properties.

参考文献/References:

［1］　LEE K Y，MOONEY D J. Hydrogels for tissue engineering ［J］. Chemical Reviews，2001，101（7）：1869-1879. ［2］　HOFFMAN A S. Hydrogels for biomedical applications ［J］. Advanced Drug Delivery Reviews，2012，64：18-23. ［3］　SUN P， ZHANG H ，XU D， et al. Super tough bilayer actuators based on multi-responsive hydrogels crosslinked by functional triblock copolymer micelle macro-crosslinkers ［J］. Journal of Materials Chemistry B，2019，7（16）：2619-2625. ［4］　NAAHIDI S， JAFARI M， LOGAN M， et al. Biocompatibility of hydrogel-based scaffolds for tissue engineering applications ［J］. Biotechnology Advances，2017，35（5）：530-544. ［5］　GHOLAMALII I， HOSSEINI S N， ALIPOUR E，et al. Preparation and characterization of oxidized starch/CuO nanocomposite hydrogels applicable in a drug delivery system ［J］. Starch，2019，71（3/4）：1800118（1）- 1800118（8）. ［6］　XIN T W， MAO J N， LIU L L， et al. Programmed sustained release of recombinant human bone morphogenetic protein-2 and inorganic ion composite hydrogel as artificial periosteum ［J］. ACS Applied Materials & Interfaces，2020，12（6）：6840-6851. ［7］　杨婉，王映桂，孙鹏，等. 琼脂糖凝胶中树枝状银的生长研究［J］. 武汉工程大学学报，2017，39（3）： 248-252. ［8］　TAYLOR D L，PANHUIS M I H. Self-healing hydrogels ［J］. Advanced Materials，2016，28（41）：9060-9093. ［9］　GUO B L，QU J，ZHAO X，et al. Degradable conductive self-healing hydrogels based on dextran-graft- tetraaniline and N-carboxyethyl chitosan as injectable carriers for myoblast cell therapy and muscle regeneration ［J］. Acta Biomaterialia，2019，84：180-193. ［10］　李进，赵梓年，李征征，等. 自愈合水凝胶的合成机理及生物医学应用［J］. 材料导报，2019，33（19）：3328-3335，3346. ［11］　何广华，赵洒，王海波，等. 羧乙基壳聚糖/聚乙烯醇自愈水凝胶的制备及其性能［J］. 武汉大学学报（理学版），2019，65（4）：369-376. ［12］　THOMBARE N， MISHAR S， SIDDIQUI M Z，et al. Design and development of guar gum based novel，superabsorbent and moisture retaining hydrogels for agricultural applications ［J］. Carbohydrate Polymers，2018，185：169-178. ［13］　THOMBARE N， JHA U， MISHRA S，et al. Guar gum as a promising starting material for diverse applications： a review ［J］. International Journal of Biological Macromolecules，2016，88：361-372. ［14］　ALVAREZ-LORENZO C，BLANCO-FEMANDEZ B，PUGA A M，et al. Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery ［J］. Advanced Drug Delivery Reviews，2013，65（9）：1148-1171. ［15］　CHANDY T，SHARMA C P. Chitosan-as a biomaterial ［J］. Biomaterials，Artificial Cells and Artificial Organs，1990，18（1）：1-24. ［16］　BHATTARAI N，GUNN J，ZHANG M Q. Chitosan- based hydrogels for controlled，localized drug delivery ［J］. Advanced Drug Delivery Reviews，2010，62（1）：83-99. ［17］　LIU Q Y，DONG Z Y，DING Z Y，et al. Electroresponsive homogeneous polyelectrolyte complex hydrogels from naturally derived polysaccharides ［J］. ACS Sustainable Chemistry & Engineering，2018，6（5）：7052-7063. ［18］　YU F，CAO X D，DU J，et al. Multifunctional hydrogel with good structure integrity，self-healing，and tissue- adhesive property formed by combining Diels-Alder click reaction and acylhydrazone bond ［J］. ACS Applied Materials & Interfaces，2015，7（43）：24023-24031. ［19］　DODI G， HRITCU D， POPA M I， et al. Carboxymethylation of guar gum：synthesis and characterization ［J］. Cellulose Chemistry and Technology，2011，45（3/4）：171-176. ［20］　CHEN T，CHEN Y J，REHMAN H U，et al. Ultratough，self-healing，and tissue-adhesive hydrogel for wound dressing ［J］. ACS Applied Materials & Interfaces，2018，10（39）：33523-33531.

相似文献/References:

[1]许莉莉,刘玉兰,周敏,等.微波催化法制备壳聚糖及其膜性能研究[J].武汉工程大学学报,2008,(03):72.
　XU Li li,LIU Yu lan,ZHOU Min,et al.The preparation of chitosan under microwave radiation and the properties of its film[J].Journal of Wuhan Institute of Technology,2008,(03):72.
[2]蔡惠,廖华玲,刘义,等.对甲基苯酚在PLYS/TiO2CS修饰电极上的电化学行为[J].武汉工程大学学报,2011,(12):13.
　CAI Hui,LIAO Hua ling,LIU Yi,et al.Electrochemical behavior of pcresol on Poly(Lysine)/nanoTiO2chitosan modified electrodes and its determination[J].Journal of Wuhan Institute of Technology,2011,(03):13.
[3]胡文云,卢桦.壳聚糖絮凝剂去除水源水浊度[J].武汉工程大学学报,2013,(01):12.[doi:16742869(2013)01001205]
　HU Wen yun,LU hua.Chitosan coagulant on treating turbidity of drinking water source[J].Journal of Wuhan Institute of Technology,2013,(03):12.[doi:16742869(2013)01001205]
[4]柏正武,付克勤,宾琴,等.不同分子量超高脱乙酰度壳聚度糖的制备[J].武汉工程大学学报,2014,(08):16.[doi:103969/jissn16742869201408003]
　BAI Zheng wu,FU Ke qin,BIN Qin,et al.Preparation of chitosan with various molecular weight and ultrahigh degree of deacetylaion[J].Journal of Wuhan Institute of Technology,2014,(03):16.[doi:103969/jissn16742869201408003]
[5]魏端丽,姚炜钦,喻湘华,等.聚乙烯醇-壳聚糖复合海绵的制备及性能[J].武汉工程大学学报,2016,38(06):549.[doi:10. 3969/j. issn. 1674-2869. 2016. 06. 007]
　WEI Duanli,YAO Weiqin,YU Xianghua,et al.Synthesis and Properties of Polyvinyl Alcohol-Chitosan Composite Sponges[J].Journal of Wuhan Institute of Technology,2016,38(03):549.[doi:10. 3969/j. issn. 1674-2869. 2016. 06. 007]
[6]张子俊,李　慧,张媛媛,等.基于纳米钯/石墨烯增敏效应对双酚A的电化学检测[J].武汉工程大学学报,2017,39(01):5.[doi:10. 3969/j. issn. 1674?2869. 2017. 01. 002]
　ZHANG Zijun,LI Hui,ZHANG Yuanyuan,et al.Bisphenol A Based on Enhancement Effect of Palladium Nanoparticle/Graphene[J].Journal of Wuhan Institute of Technology,2017,39(03):5.[doi:10. 3969/j. issn. 1674?2869. 2017. 01. 002]
[7]梁　爽,宾　琴,柏正武,等.壳聚糖衍生物手性固定相的制备及其分离性能[J].武汉工程大学学报,2017,39(04):320.[doi:10. 3969/j. issn. 1674?2869. 2017. 04. 003]
　LIANG Shuang,BIN Qing,BAI Zhengwu,et al.Preparation and Enantioseparation Performance of Chiral Stationary Phases Derived from Chitosan Derivatives[J].Journal of Wuhan Institute of Technology,2017,39(03):320.[doi:10. 3969/j. issn. 1674?2869. 2017. 04. 003]
[8]熊金辉,柏正武*.壳聚糖氨基选择性功能化中的空间位阻效应[J].武汉工程大学学报,2019,(04):322.[doi:10. 3969/j. issn. 1674?2869. 2019. 04. 004]
　XIONG Jinhui,BAI Zhengwu*.Influence of Steric Hindrance on Amino-Selective Functionalization of Chitosan[J].Journal of Wuhan Institute of Technology,2019,(03):322.[doi:10. 3969/j. issn. 1674?2869. 2019. 04. 004]
[9]赵启天,杨　隽*,舒何进,等.壳聚糖螯合吸附剂的制备及其在尾矿坝中的应用[J].武汉工程大学学报,2020,42(01):50.[doi:10.19843/j.cnki.CN42-1779/TQ.201907004]
　ZHAO Qitian,YANG Jun*,SHU Hejin,et al.Preparation of Chitosan Chelate Adsorbent and Its Application in Tailings Dam[J].Journal of Wuhan Institute of Technology,2020,42(03):50.[doi:10.19843/j.cnki.CN42-1779/TQ.201907004]
[10]张宇航,熊金辉,何保江,等.壳聚糖-苄基脲衍生物手性固定相的制备与性能[J].武汉工程大学学报,2020,42(04):366.[doi:10.19843/j.cnki.CN42-1779/TQ.201911021]
　ZHANG Yuhang,XIONG Jinhui,HE Baojiang,et al.Preparation and Properties of Chiral Stationary Phase Drived from Chitosanbenzylurea Derivative[J].Journal of Wuhan Institute of Technology,2020,42(03):366.[doi:10.19843/j.cnki.CN42-1779/TQ.201911021]

备注/Memo

备注/Memo:
收稿日期：2020-02-01基金项目：武汉工程大学第九届研究生教育创新基金（CX2017007）作者简介：王映桂，硕士研究生。E-mail： wangyinggui1993@163.com*通讯作者：吴江渝，博士，教授。E-mail： wujy@wit.edu.cn引文格式：王映桂，张思洁，刘璨，等. 可降解自愈合壳聚糖/瓜尔胶水凝胶的制备与性能［J］. 武汉工程大学学报，2020，42（3）：302-306.
更新日期/Last Update: 2020-07-09