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[1]郭远哲,毛思颖,罗晓刚*.原位制备ZIF-8/纤维素微球及其控制释放5-氟尿嘧啶的研究[J].武汉工程大学学报,2024,46(02):137-147.[doi:10.19843/j.cnki.CN42-1779/TQ.202303020]
　GUO Yuanzhe,MAO Siying,LUO Xiaogang*.ZIF-8/cellulose microspheres prepared in situ tocontrol release of 5-fluorouracil[J].Journal of Wuhan Institute of Technology,2024,46(02):137-147.[doi:10.19843/j.cnki.CN42-1779/TQ.202303020]
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原位制备ZIF-8/纤维素微球
及其控制释放5-氟尿嘧啶的研究
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
46
期数:
2024年02期
页码:
137-147
栏目:
材料科学与工程
出版日期:
2024-04-28

文章信息/Info

Title:
ZIF-8/cellulose microspheres prepared in situ to
control release of 5-fluorouracil
文章编号:
1674 - 2869（2024）02 - 0137- 11
作者:
郭远哲1; 毛思颖1; 罗晓刚*1; 2
1. 武汉工程大学化工与制药学院，绿色化工过程教育部重点实验室（武汉工程大学），湖北 武汉 430205；
2. 湖北三峡实验室，湖北 宜昌 443007
Author(s):
GUO Yuanzhe1; MAO Siying1; LUO Xiaogang*1; 2
1. School of Chemical Engineering and Pharmacy，Wuhan Institute of Technology；Key Laboratory of Green Chemical Process of Ministry of Education（Wuhan Institute of Technology），Wuhan 430205，China；
2. Hubei Three Gorges Laboratory，Yichang 443007，China
关键词:
纤维素微球; ZIF-8; 5-氟尿嘧啶; 控制释放
Keywords:
cellulose microspheres;  ZIF-8;  5-fluorouracil;  controlled release
分类号:
X703
DOI:
10.19843/j.cnki.CN42-1779/TQ.202303020
文献标志码:
A
摘要:
在纤维素微球（CM）上设计了沸石型咪唑骨架材料8/纤维素复合微球（ZIF-8@CM）作为5-氟尿嘧啶（5-FU）的载体并对5-FU进行控制释放。以CM、硝酸锌和2-甲基咪唑为原料，采用原位法制备了ZIF-8@CM。通过氢键、静电相互作用和π-π堆积作用将5-FU加载到ZIF-8@CM上。利用扫描电子显微术、能量色散X射线分析法、傅里叶变换红外光谱法、X射线衍射、X射线光电子能谱法和热重分析对样品进行表征，结果表明成功制备了ZIF-8@CM，并在ZIF-8@CM上成功加载了5-FU。ZIF-8@CM对5-FU的负载量可达74.10 mg·g-1，远高于CM（2.84 mg·g-1）。此外，ZIF-8@CM-5-FU可在pH=5.0的磷酸缓冲溶液（PBS）环境下持续释放5-FU 600 min，释放量达到63.4%，但在pH=7.4的PBS环境下仅释放37.6%。5-FU的释放遵循一级动力学和Fickian扩散机制。在细胞实验中已证实ZIF-8@CM具有良好的生物相容性和极低的细胞毒性，是5-FU安全释放的合适载体。本研究为设计一种5-FU的新型载体提供了思路。

Abstract:
Zeolitic imidazole framework 8/cellulose composite microsphere（ZIF-8@CM） was designed on the cellulose microsphere（CM） as the carrier of 5-fluorouracil（5-FU） to control the release of 5-FU. ZIF-8@CM was prepared by an in-situ method from CM，zinc nitrate and 2-methylimidazole. 5-FU was loaded on ZIF-8@CM by hydrogen bonding， electrostatic interaction and π-π stacking. The samples were characterized by scanning electron microscopy， energy-dispersion X-ray analysis， Fourier transform infrared spectroscopy， X-ray diffraction， X-ray photoelectron spectroscopy and thermogravimetric analysis. The results show that ZIF-8@CM is successfully prepared and 5-FU is loaded on ZIF-8@CM. The loading capacity of 5-FU can reach 74.10 mg·g-1，much higher than that of CM （2.84 mg·g-1）. In addition，ZIF-8@CM-5-FU can release 63.4% of 5-FU over 600 min in phosphoric acid buffer solution （PBS） at pH=5.0，but only 37.6% in PBS at pH=7.4. The release of 5-FU follows first-order kinetics and Fickian diffusion mechanism. Cell experiments prove that ZIF-8@CM have good biocompatibility and very low cytotoxicity，and ZIF-8@CM-5-FU is a suitable vector for safe release of 5-FU. This study provides an idea for designing a new type of 5-FU carrier.

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备注/Memo

备注/Memo:
收稿日期：2023-03-14
基金项目：国家自然科学基金（51773159）
作者简介：郭远哲，硕士研究生。Email：1056624216@qq.com
*通信作者：罗晓刚，博士，教授。Email：xgluo0310@hotmail.com
引文格式：郭远哲，毛思颖，罗晓刚. 原位制备ZIF-8/纤维素微球及其控制释放5-氟尿嘧啶的研究［J］. 武汉工程大学学报，2024，46（2）：137-147.
更新日期/Last Update: 2024-05-01