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[1]马徐民,田 凤,胡美纯*,等.小分子石蒜碱抗肿瘤作用的研究进展[J].武汉工程大学学报,2019,(04):327-333.[doi:10. 3969/j. issn. 1674?2869. 2019. 04. 005]
 MA Xumin,TIAN Feng,HU Meichun*,et al.Research Progress in Antitumor Effects of Small Molecule Lycorine[J].Journal of Wuhan Institute of Technology,2019,(04):327-333.[doi:10. 3969/j. issn. 1674?2869. 2019. 04. 005]
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小分子石蒜碱抗肿瘤作用的研究进展(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2019年04期
页码:
327-333
栏目:
化学与化学工程
出版日期:
2019-09-27

文章信息/Info

Title:
Research Progress in Antitumor Effects of Small Molecule Lycorine
文章编号:
20190404
作者:
马徐民田 凤胡美纯*王 华*
湖北科技学院药学院;基础医学院基础医学研究中心,湖北 咸宁 437100
Author(s):
MA Xumin TIAN Feng HU Meichun* WANG Hua*
College of Pharmacy; Research Center of Basic Medical Sciences, College of Basic Medicine, Hubei University of Science and Technology, Xianning 437100, China
关键词:
石蒜碱肿瘤信号通路
Keywords:
lycorine tumor signaling pathway
分类号:
R93
DOI:
10. 3969/j. issn. 1674?2869. 2019. 04. 005
文献标志码:
A
摘要:
在治疗肿瘤中,小分子靶向药物与传统药物相比,因具有毒副作用更小、特异性更高和容易通过血脑屏障等特点,成为近年来抗肿瘤药物的研究热点。小分子石蒜碱是药用植物石蒜鳞茎的一种生物碱,具有抗炎,抗病毒等多种生物学活性,并且对多种肿瘤具有较好的抑制作用。综述了小分子石蒜碱在抗肿瘤方面的作用机制,石蒜碱主要通过诱导肿瘤细胞凋亡,抑制并阻断细胞周期,抑制肿瘤血管生成以及介导细胞自噬来抑制肿瘤的生长。与纳米技术相结合,石蒜碱药物研发将为新型抗癌药物的设计提供新的思路。
Abstract:
Small molecule drugs have been attracting attentions with their less side effects, higher specificity in tumour therapy, and more easily getting through blood-brain-barrier compared to the traditional medicines. lycorine is one kind of alkaloids originated and extracted from medicinal plant lycoris radiate bulbs, possesses biological activities of anti-inflammatory, anti-virus and anti-tumor. We summarized the anticancer mechanisms of small molecule lycorine, including inhibiting the growth of tumors by inducing tumor cell apoptosis, blocking cell cycle, prohibiting tumor angiogenesis and suppressing cell autophagy. Combined with nano-technology, the development of lycorine drugs will provide a new insight in the design of anticancer drug.

参考文献/References:

[1] RUSSO M,RUSSO G L,DAGLIA M,et al. Understanding genistein in cancer:the “good” and the “bad” effects: a review[J]. Food Chemistry,2016,196:589-600. [2] WE Library. National bureau of statistics of China. China statistical yearbook[M]. Beijing: China Statistics Press,2010. [3] MRIDUL R, LIANG L, XIAO X J, et al. Lycorine:a prospective natural lead for anticancer drug discovery[J]. Biomedicine & Pharmacotherapy,2018,107:615-624. [4] 李健,于淼,高世勇,等. 石蒜科植物中生物碱的药理作用研究[J]. 哈尔滨商业大学学报(自然科学版),2014,30(2):168-171. [5] JIMENEZ A,SANTOS A M,ALONSO G,et al. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids[J]. Acta Biochimica et Biophysica Sinica,1976,425(3):342-348. [6] 果婷婷,王辉强,李玉环,等. 石蒜碱及其衍生物的药理作用研究进展[J]. 中国医药生物技术,2018,13(5):463-466. [7] 李捷萌,陈彦青,刘荣国. 线粒体凋亡途径与Bcl-2家族蛋白研究进展[J]. 医学综述,2008,14(4):489-490. [8] CZABOTAR P E, LESSENE G, STRASSER A,et al. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy[J]. Nature Reviews Molecular Cell Biology,2014,15(1):49-63. [9] MARINO G, NISO S M, BAEHRECKE E H, et al. Self-consumption: the interplay of autophagy and apoptosis[J]. Nature Reviews Molecular Cell Biology,2014,15(2):81-94. [10] RIEDL S J, SHI Y. Molecular mechanisms of caspase regulation during apoptosis,Nat[J]. Nature Reviews Molecular Cell Biology,2004,5(11):897-907. [11] YU H Y, QIU Y L, PANG X, et al. Lycorine promotes autophagy and apoptosis via TCRP1/Akt/mTOR axis inactivation in human hepatocellular carcinoma[J]. Molecular Cancer Therapeutics,2017,16(12):2711-2723. [12] ZENG H, FU R, YAN L X, et al. Lycorine induces apoptosis of A549 Cells via AMPK-Mammalian target of rapamycin (mTOR)-S6K signaling pathway[J]. Medical Science Monitor,2017,28(23):2035-2041. [13] LI X Z,XU P,WANG C S,et al. Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma[J]. Oncotarget,2017,8(13):21177-21186. [14] WANG C S, WANG Q R, LI X Z, et al. Lycorine induces apoptosis of bladder cancer T24 cells by in- hibiting phospho-Akt and activating the intrinsic apoptotic cascade[J]. Biochemical and Biophysical Research Communications,2017,483(1):197-202. [15] YING X X, HUANG A L, XING Y J, et al. Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway[J]. Science China Life Sciences,2017,27 (10):16-368. [16] HU M C, PENG S H, HE Y D, et al. Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer[J]. Oncotarget,2015,6(17):15348-15361. [17] LI Y B,YU M,QI Z,et al. Study on apoptosis effect of human breast cancer cell MCF-7 induced by lycorine hydrochloride via death receptor pathway[J]. Saudi Pharmaceutical Journal,2017,25(4):633-637. [18] WANG J,XU J,XING G Q. Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway[J]. Acta Biochimica et Biophysica Sinica (Shanghai),2017,49(9): 771-779. [19] HUA D H,SAHA S,TAKEMOTO D J. Anticancer activities of 2,5,8,9-substituted 6-oxo-1,2,3,4,5,6-hexahydrophenanthridines on multi-drug-resistant phenotype cells[J]. Anticancer Research,1997,17(4A):2435-2441. [20] VAN G G,ANDOLFI A,LALLEMAND B,et al. Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells[J]. Journal of Natural Products,2010,73(7):1223-1227. [21] RIEDL S J,SHI Y. Molecular mechanisms of caspase regulation during apoptosis[J]. Nature Reviews Molecular Cell Biology,2004,5(11):897-907. [22] LI Y,LIU J,TANG L J,et al. Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest[J]. Oncology Reports,2007,17(2):377-384. [23] CZABOTAR P E, LESSENE G, STRASSER A,et al. Control of apoptosis by the BCL-2 protein family:implications for physiology and therapy[J]. Nature Reviews Molecular Cell Biology,2014,15(1):49-63. [24] LIU X S, JIANG J K, JIAO X Y, et al. Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells[J]. Cancer Letters,2009,274(1):16-24. [25] CARNEIRO B A, MEEKS J J, KUZEL T M,et al. Emerging therapeutic targets in bladder cancer[J]. Cancer Treatment Reviews,2015,41(2):170-178. [26] LIU X S, JIANG J K, JIAO X Y, et al. Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77[J]. Tumour Biology,2015,36(4):2937-2945. [27] LI L, DAI H J, YE M,et al. Lycorine induces cell- cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition[J]. Cancer Cell International,2012,12(1):1475-2867. [28] CAO Z F,YU D,FU S L,et al. Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity[J]. Toxicology Letters,2013,218(2):174-185. [29] BRUQAROLAS J, MOBERQ K, BOYD S D, et al. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation[J]. Proceedings of The National Academy of Sciences of The United States of America,1999,96(3):1002-1007. [30] BARTEK J, LUKAS J. Chk1 and Chk2 kinases in checkpoint control and cancer[J]. Cancer Cell,2003,3(5):421-429. [31] ROKUDAI S,AIKAWA Y,TAGATA Y,et al. Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest[J]. Journal of Biological Chemistry,2009,284(1):237-244. [32] LIU J,HU J L,SHI B W,et al. Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells[J]. Cancer Cell International,2010,10(25):1475-2867. [33] 郭小波,耿庆,张楠,等. 自噬在肺癌中的研究进展[J]. 医学综述,2019(5):888-892. [34] KLIONSK D J. Autophagy: from phenomenology to molecular understanding in less than a decade[J] . Nature Reviews Molecular Cell Biology,2007,8(11):931-937. [35] ZHAO S, MA C M, LIU C X, et al. Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells[J]. International Journal of Molecular Medicine,2012,30(4):939-944. [36] JESSICA A B,SHETAL A P, CELESTE S M. The impact of O2 availability on human cancer[J]. Nature Reviews Cancer,2008,8(12):967-975. [37] ZHANG H R, CHEN J M, ZENG Z Y, et al. Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro[J]. International Journal of Molecular Medicine,2013,31(5):1127-1134. [38] LIVESEY K M, KANG R, VERNON P, et al. p53/HMGB1 complexes regulate autophagy and apoptosis[J] . Cancer Research,2012,72(8):1996-2005. [39] MORSELLI E, SHEN S S, RUCKENSTUHL C, et al. p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200[J]. Cell Cycle,2011,10(16):2763-2769. [40] KANG R, LOUX T, TANG D L, et al. The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia[J]. Proceedings of The National Academy of Sciences of The United States of America,2012,109(18):7031-7036. [41] KANG R,CHEN R C, ZHANG Q H, et al. HMGB1 in health and disease[J]. Molecular Aspects of Medicine,2014,40:1-116. [42] KANG R, ZHANG Q H, ZEH H J,et al. HMGB1 in cancer: good, bad, or both?[J]. Clinical Cancer Research,2013,19(15):4046-4057. [43] TANG D,KANG R,CHEH C W,et al. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells[J]. Oncogene,2010,29(38):5299-5310. [44] DONG X,ITO N,LOTZE M,et al. High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy[J]. Journal of Immunotherapy,2007,30(6):596-606. [45] TANG D L, KANG R, LIVESEY K M, et al. High- mobility group box 1 is essential for mitochondrial quality control[J] . Cell Metabolism,2011,13(6):701-711. [46] YAGHOUTI N, BOOSTANI R, MOHAMAMDI A,et al. Role of receptors for advanced glycation end products and high-mobility group box 1 in the outcome of human t cell lymphotropic type 1 infection[J]. Viral Immunology,2019,32(2):89-94. [47] FEI Q, XIAO J J, GAI L, et al. HMGB1-RAGE signaling facilitates ras-dependent Yap1 expression to drive colorectal cancer stemness and development[J]. Molecular Carcinogenesis,2019,58(4):500-510. [48] ROY M, LIANG L, XIAO X J, et al. Lycorine downregulates HMGB1 to inhibit autophagy and enhances bortezomib activity in multiple myeloma[J]. Theranostics,2016,6(12):2209-2224. [49] YING X X,HUANG A L,XING Y J,et al. Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway[J]. Science China-Life Sciences,2017,60(4):417-428. [50] LO H W,HSU S C,XIA W Y,et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial- mesenchymal transition in cancer cells via up-regulation of TWIST gene expression[J]. Cancer Research,2007,67(19):9066-9076. [51] YANG M H, WU K J. TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development[J]. Cell Cycle,2008,7(14):2090-2096. [52] BORDELEAU F, MASON B N,LOLLIS E M,et al. Matrix stiffening promotes a tumor vasculature phenotype[J]. Proceedings of The National Academy of Sciences of the United States of America,2017,114(3):492-497. [53] HOLDERFIELD M T,HUGHES C C. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis[J]. Circulation Research,2008,102(6):637-652. [54] SHEN J, ZHANG T, CHENG Z, et al. Lycorine inhibits glioblastoma multiforme growth through EGFR suppression[J]. Journal of Experimental & Clinical Cancer Research,2018,37(1):157. [55] 曹雪,王晓非. 血管内皮钙黏蛋白的研究进展及临床意义[J]. 医学综述,2017,23(17):3354-3358. [56] 刘瑞芳. 中草药单体石蒜碱和药根碱的抗黑色素瘤新生血管形成作用及其机制[D]. 苏州:苏州大学,2012. [57] LIU R F,CAO Z F,TU J,et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry[J]. Pigment Cell & Melanoma Research,2012,25(5):630-638. [58] KHAN M N,HAGGAG Y A,LANE M E,et al. Polymeric nano-encapsulation of curcumin enhances its anti-cancer activity in breast (MDA-MB231) and lung (A549) cancer cells through reduction in expression of HIF-1α and nuclear p65 (Rel A)[J]. Current Drug Delivery,2018,15(2):286-295. [59] KARMAKAR A, XU Y, MUSTAFA T, et al. Nanodelivery of parthenolide using functionalized nanographene enhances its anticancer activity[J]. RSC Advances,2015,5(4):2411-2420.

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备注/Memo

备注/Memo:
收稿日期:2019-05-07基金项目:国家自然科学基金(81702985,81602649);湖北科技学院博士启动基金(BK1508)作者简介:马徐民,硕士研究生。E-mail:454705998@qq.com*通讯作者:王 华,博士,讲师,硕士研究生导师。E-mail:whlei@alumni.hust.edu.cn 胡美纯,博士,副教授,硕士研究生导师。E-mail: humeichun.530@163.com引文格式:马徐民,田凤,胡美纯,等. 小分子石蒜碱抗肿瘤作用的研究进展[J]. 武汉工程大学学报,2019,41(4):327-333.
更新日期/Last Update: 2019-08-05